Studies of aqueous humor dynamics in man. II. Measurements in young normal subjects using acetazolamide and L-epinephrine.

The short-term effects on aqueous humor flow dynamics of single doses of acetazolamide and L-epinephrine, alone and combined, were studied in selected young, normal men. Analysis of aqueous flow before and after medication was facilitated, by graphic representation of flow versus intraocular pressure, the flow curve. Acetazolamide reduced intraocular pressure and Pk of Goldmann without affecting true facility or pseudofacility. A pattern of pressureindependent reduction of flow occurred. x,-Epinephrine reduced intraocular pressure and pseudofacility. A pattern of pressure-dependent change of aqueous flow occurred with, reduction of flow at intraocular pressures below approximately 30 mm. Hg. When acetazolamide was combined with epinephrine, additive effects were noted, with an additional decrease of intraocular pressure associated with significant increase of true facility. No change of true facility occurred after epinephrine or acetazolamide alone in these subjects.